The phrase "tickles pink" means to make someone extremely happy or delighted. There are many antonyms for this phrase, depending on the level of displeasure or sadness one wishes to convey. For instance, "pisses off" is a popular antonym that expresses extreme anger or annoyance. Other antonyms like "disappoints," "saddens," or "frustrates" might connote varying levels of displeasure or dissatisfaction. If one simply wants to express mild displeasure or annoyance, then antonyms such as "bothers" or "irritates" might be useful. Ultimately, the appropriateness of the antonym used will depend on the context and the emotions the speaker wishes to convey.